Introducing Comara Signal

Early warning
for the brain.

Comara Signal monitors cognitive health through natural conversation at home — generating continuous biomarker signals long before clinical symptoms emerge.

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Patent Pending Not a diagnostic tool Built in Australia Grounded in published neuroscience
50M+
people living with dementia worldwide — most diagnosed far too late
Years
before clinical symptoms, speech biomarkers begin to diverge
~0
continuous cognitive monitoring tools available at home, until now
7
cognitive biomarker domains tracked per conversation in real time
The problem

Detected too late.
Treated too little.

Cognitive decline is most treatable in its earliest stages — yet current detection relies on infrequent, expensive clinical assessments that most people never receive until symptoms are obvious.

By the time a GP refers for cognitive testing, the window for effective intervention is often already closing. Comara Signal changes that.

Typical detection timeline
Years 0–5 · Subtle linguistic change begins Sentence complexity, word-finding pauses, lexical richness all shift — imperceptibly in conversation, but measurable in data.
Comara Signal detects here
Years 5–10 · Mild Cognitive Impairment (MCI) Memory lapses, reduced verbal fluency. Family notices something is off. Still largely undiagnosed.
Often missed clinically
Years 10–15 · Clinical presentation Symptoms are now significant. Assessment triggered. Diagnosis confirmed — years after the optimal intervention window.
Typical detection point
How it works

A conversation.
That's all it takes.

Cara, our AI companion, conducts natural conversations that feel like a friendly check-in — while Comara Signal extracts clinical-grade biomarker signals in real time.

Step 01
💬

Natural conversation

The participant has a brief, relaxed conversation with Cara — an AI companion designed to be warm, engaging, and unobtrusive. No tests, no clinical feel, no stress.

→
Step 02
📡

Real-time signal extraction

Comara Signal analyses speech patterns across 7 cognitive domains — semantic coherence, lexical richness, fluency, memory, syntax and more — as the conversation unfolds.

→
Step 03
📊

Longitudinal intelligence

Signals are tracked over time, building a longitudinal cognitive profile. Clinicians, aged care providers and researchers receive structured, actionable biomarker data — not raw transcripts.

Biomarker intelligence

7 cognitive domains.
Tracked continuously.

Each biomarker is grounded in decades of established neuroscience and linguistics research — now made continuous and accessible for the first time.

Semantic Coherence
Measures logical flow and meaning consistency across an utterance — a reliable early marker of executive function decline.
Lexical Richness
Vocabulary diversity and word-finding ease. Progressive decline in lexical variety is among the earliest detectable signals of Alzheimer's-type dementia.
Verbal Fluency
Smooth, spontaneous speech production. Disruptions in fluency — hesitations, false starts, fillers — correlate with processing speed and language network integrity.
Memory Consistency
Tracks whether facts, details and self-reported events remain consistent across sessions — a longitudinal marker of episodic memory function.
Syntactic Complexity
Sentence structure depth and grammatical complexity. Simplified syntax is an early and consistent indicator of declining linguistic processing capacity.
Emotional Tone
Sentiment variability and affect expression. Changes in emotional range and self-reported wellbeing are correlated with MCI and early dementia progression.
Pragmatic Language
The social and contextual appropriateness of language — topic maintenance, turn-taking, relevance and inference. Disruptions in pragmatic function are a well-established marker of frontotemporal and Alzheimer's-type dementia, often visible years before formal diagnosis.
Who it's for

Built for the people
who care most.

Comara Signal serves three distinct customer segments — each with a critical need for continuous, low-burden cognitive monitoring at scale.

Primary Care · GPs

General Practitioners

Enable proactive cognitive monitoring between appointments. Receive structured longitudinal signals — not vague family concerns — when it's time to act.

  • Longitudinal biomarker trends over months and years
  • Structured referral evidence at GP visits
  • No extra clinical burden per assessment
  • Patient-reported, home-based monitoring
Care Delivery

Aged Care Providers

Continuous cognitive monitoring for residents and home care clients — at scale, without clinical overhead. Detect changes early, intervene faster, document better.

  • Daily or weekly automated sessions with residents
  • Population-level dashboard for care coordinators
  • Early detection triggers escalation workflows
  • Medication and intervention correlation tracking
Research

Clinical Trial Teams

Replace expensive, infrequent neuropsychological assessments with continuous, automated cognitive biomarker collection. Lower cost per data point. Higher data density.

  • Continuous longitudinal data with no site visits
  • Treatment response signals between assessments
  • Structured export for statistical analysis
  • Pharmaceutical-grade audit trail and data integrity
The science

The science has always been there.

We've made it continuous for the first time.

🔬
Established neuroscience Speech and language biomarkers for cognitive decline are grounded in decades of published clinical research — DementiaBank, ADNI, and leading academic institutions worldwide.
📈
Longitudinal by design Single assessments are noisy. Comara Signal's value compounds with every session — building a personal baseline and tracking deviation over time, not just a snapshot.
🏠
Ecologically valid Assessments in natural home environments are more representative of real cognitive function than clinic-based testing — reducing white coat anxiety and performance effects.
⚠️
Not a diagnostic tool Comara Signal surfaces signals for clinical consideration — it does not diagnose, treat, or replace clinical assessment. All outputs are intended for qualified clinician review.
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Continuous cognitive monitoring, at home, through natural conversation. The science is established. We've made it continuous for the first time.

Comara Intelligence · Founding Thesis

Ready to see
Comara Signal in action?

We're working with a small group of clinical and research partners. If you're a GP, aged care provider, or clinical trial team — we'd love to talk.

Request a demo Brand guidelines